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| Latest Insider Trading | Top Insider Trading Recent Week | Top 10% Owner Trading Recent Week | Filter
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| Ticker | Owner | Relationship | Date | Transaction | Cost  |
#Shares | Value ($) | #Shares Total | SEC Form 4 |
|---|---|---|---|---|---|---|---|---|---|
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Apr 12 '25 | Option Exercise | 0.00 | 3,125 | 0 | 363,924 | Apr 14 07:10 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Mar 23 '25 | Option Exercise | 0.00 | 11,086 | 0 | 365,162 | Mar 25 06:11 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Feb 21 '25 | Sale | 98.78 | 8,334 | 823,240 | 354,076 | Feb 24 04:31 PM |
| PI | DIORIO CHRIS PH.D. | Officer | Feb 21 '25 | Proposed Sale | 98.78 | 8,334 | 823,240 | Feb 21 04:07 PM | |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Feb 10 '25 | Option Exercise | 22.40 | 10,000 | 224,000 | 343,856 | Feb 12 05:22 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Jan 12 '25 | Option Exercise | 0.00 | 3,125 | 0 | 334,697 | Jan 14 04:49 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Jan 13 '25 | Sale | 141.02 | 841 | 118,600 | 333,856 | Jan 14 04:49 PM |
| PI | DIORIO CHRIS PH.D. | Officer | Jan 13 '25 | Proposed Sale | 141.02 | 841 | 118,600 | Jan 13 04:43 PM | |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Dec 23 '24 | Option Exercise | 0.00 | 3,818 | 0 | 333,076 | Dec 26 05:00 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Dec 24 '24 | Sale | 146.22 | 1,504 | 219,912 | 331,572 | Dec 26 05:00 PM |
| PI | DIORIO CHRIS PH.D. | Officer | Dec 24 '24 | Proposed Sale | 146.22 | 1,504 | 219,912 | Dec 26 11:40 AM | |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Nov 07 '24 | Option Exercise | 33.77 | 25,000 | 844,250 | 341,848 | Nov 08 04:31 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Nov 06 '24 | Option Exercise | 33.77 | 25,000 | 844,250 | 364,438 | Nov 08 04:31 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Nov 06 '24 | Sale | 204.17 | 12,590 | 2,570,516 | 351,848 | Nov 08 04:31 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Nov 07 '24 | Sale | 198.87 | 12,590 | 2,503,745 | 329,258 | Nov 08 04:31 PM |
| PI | DIORIO CHRIS PH.D. | Officer | Nov 07 '24 | Proposed Sale | 198.87 | 12,590 | 2,503,745 | Nov 07 04:42 PM | |
| PI | DIORIO CHRIS PH.D. | Officer | Nov 06 '24 | Proposed Sale | 204.17 | 12,590 | 2,570,516 | Nov 06 04:09 PM | |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Oct 29 '24 | Option Exercise | 22.40 | 34,474 | 772,218 | 328,912 | Oct 31 05:28 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Oct 30 '24 | Option Exercise | 22.40 | 526 | 11,782 | 294,964 | Oct 31 05:28 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Oct 30 '24 | Sale | 195.51 | 526 | 102,839 | 294,438 | Oct 31 05:28 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Oct 29 '24 | Sale | 201.51 | 34,474 | 6,946,979 | 294,438 | Oct 31 05:28 PM |
| PI | DIORIO CHRIS PH.D. | Officer | Oct 30 '24 | Proposed Sale | 195.51 | 526 | 102,839 | Oct 30 04:02 PM | |
| PI | DIORIO CHRIS PH.D. | Officer | Oct 29 '24 | Proposed Sale | 201.51 | 34,474 | 6,946,979 | Oct 29 05:49 PM | |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Oct 12 '24 | Option Exercise | 0.00 | 3,125 | 0 | 295,657 | Oct 15 07:42 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Oct 14 '24 | Sale | 237.82 | 1,219 | 289,901 | 294,438 | Oct 15 07:42 PM |
| PI | DIORIO CHRIS PH.D. | Officer | Oct 14 '24 | Proposed Sale | 237.82 | 1,219 | 289,901 | Oct 15 10:40 AM | |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Sep 23 '24 | Option Exercise | 0.00 | 3,818 | 0 | 294,030 | Sep 25 05:44 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Sep 24 '24 | Sale | 209.12 | 1,498 | 313,257 | 292,532 | Sep 25 05:44 PM |
| PI | DIORIO CHRIS PH.D. | Officer | Sep 24 '24 | Proposed Sale | 209.12 | 1,498 | 313,257 | Sep 24 04:05 PM | |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Jul 12 '24 | Option Exercise | 0.00 | 3,125 | 0 | 292,599 | Jul 16 05:34 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Jul 15 '24 | Sale | 175.43 | 1,187 | 208,234 | 291,412 | Jul 16 05:34 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Jul 08 '24 | Option Exercise | 22.40 | 5,000 | 112,000 | 294,474 | Jul 09 07:16 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Jul 08 '24 | Sale | 162.32 | 5,000 | 811,607 | 289,474 | Jul 09 07:16 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Jul 01 '24 | Option Exercise | 22.40 | 5,000 | 112,000 | 294,474 | Jul 02 05:31 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Jul 02 '24 | Option Exercise | 22.40 | 5,000 | 112,000 | 294,474 | Jul 02 05:31 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Jul 02 '24 | Sale | 155.49 | 5,000 | 777,433 | 289,474 | Jul 02 05:31 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Jul 01 '24 | Sale | 154.03 | 5,000 | 770,135 | 289,474 | Jul 02 05:31 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Jun 23 '24 | Option Exercise | 0.00 | 3,816 | 0 | 290,993 | Jun 25 07:12 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Jun 24 '24 | Option Exercise | 22.40 | 5,000 | 112,000 | 294,474 | Jun 25 07:12 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Jun 25 '24 | Option Exercise | 22.40 | 5,000 | 112,000 | 294,474 | Jun 25 07:12 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Jun 25 '24 | Sale | 150.06 | 5,000 | 750,308 | 289,474 | Jun 25 07:12 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Jun 24 '24 | Sale | 148.01 | 6,519 | 964,880 | 289,474 | Jun 25 07:12 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Jun 15 '24 | Option Exercise | 0.00 | 1,563 | 0 | 287,793 | Jun 18 05:40 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Jun 17 '24 | Option Exercise | 22.40 | 5,000 | 112,000 | 292,177 | Jun 18 05:40 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Jun 18 '24 | Option Exercise | 22.40 | 5,000 | 112,000 | 292,177 | Jun 18 05:40 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Jun 18 '24 | Sale | 150.92 | 5,000 | 754,617 | 287,177 | Jun 18 05:40 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Jun 17 '24 | Sale | 148.68 | 5,616 | 834,959 | 287,177 | Jun 18 05:40 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Jun 10 '24 | Option Exercise | 22.40 | 5,000 | 112,000 | 291,230 | Jun 11 06:56 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Jun 11 '24 | Option Exercise | 22.40 | 5,000 | 112,000 | 291,230 | Jun 11 06:56 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Jun 11 '24 | Sale | 146.49 | 5,000 | 732,472 | 286,230 | Jun 11 06:56 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Jun 10 '24 | Sale | 147.77 | 5,000 | 738,831 | 286,230 | Jun 11 06:56 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | May 31 '24 | Option Exercise | 22.40 | 5,000 | 112,000 | 291,230 | Jun 04 05:28 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Jun 03 '24 | Option Exercise | 22.40 | 5,000 | 112,000 | 291,230 | Jun 04 05:28 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Jun 04 '24 | Option Exercise | 22.40 | 5,000 | 112,000 | 291,230 | Jun 04 05:28 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Jun 04 '24 | Sale | 164.85 | 5,000 | 824,245 | 286,230 | Jun 04 05:28 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Jun 03 '24 | Sale | 163.54 | 5,000 | 817,684 | 286,230 | Jun 04 05:28 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | May 31 '24 | Sale | 163.21 | 5,000 | 816,050 | 286,230 | Jun 04 05:28 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Apr 26 '24 | Option Exercise | 21.81 | 26,661 | 581,476 | 312,891 | Apr 30 04:43 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Apr 26 '24 | Sale | 147.02 | 26,661 | 3,919,790 | 286,230 | Apr 30 04:43 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Apr 12 '24 | Option Exercise | 0.00 | 3,125 | 0 | 287,474 | Apr 16 04:41 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Apr 15 '24 | Sale | 118.67 | 1,244 | 147,626 | 286,230 | Apr 16 04:41 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Mar 23 '24 | Option Exercise | 0.00 | 7,489 | 0 | 287,302 | Mar 26 07:54 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Mar 25 '24 | Sale | 127.19 | 2,953 | 375,595 | 284,349 | Mar 26 07:54 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Mar 15 '24 | Option Exercise | 0.00 | 1,562 | 0 | 280,425 | Mar 19 08:04 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Mar 18 '24 | Sale | 123.56 | 612 | 75,620 | 279,813 | Mar 19 08:04 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Feb 27 '24 | Option Exercise | 21.81 | 5,000 | 109,050 | 283,863 | Feb 28 04:53 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Feb 27 '24 | Sale | 105.00 | 5,000 | 525,000 | 278,863 | Feb 28 04:53 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Feb 23 '24 | Sale | 101.16 | 16,060 | 1,624,633 | 278,863 | Feb 26 08:57 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Feb 26 '24 | Sale | 105.00 | 5,000 | 525,000 | 278,863 | Feb 26 08:57 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Feb 15 '24 | Option Exercise | 21.81 | 5,000 | 109,050 | 258,311 | Feb 20 04:31 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Feb 16 '24 | Option Exercise | 21.81 | 5,000 | 109,050 | 258,311 | Feb 20 04:31 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Feb 16 '24 | Sale | 105.32 | 5,000 | 526,598 | 253,311 | Feb 20 04:31 PM |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Feb 15 '24 | Sale | 105.00 | 5,000 | 525,020 | 253,311 | Feb 20 04:31 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jan 12 '24 | Option Exercise | 0.00 | 3,125 | 0 | 254,166 | Jan 17 05:01 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jan 16 '24 | Sale | 81.16 | 855 | 69,394 | 253,311 | Jan 17 05:01 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Dec 23 '23 | Option Exercise | 0.00 | 2,594 | 0 | 252,042 | Dec 27 05:12 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Dec 26 '23 | Sale | 89.76 | 1,001 | 89,846 | 251,041 | Dec 27 05:12 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Dec 15 '23 | Option Exercise | 0.00 | 1,563 | 0 | 250,064 | Dec 19 04:41 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Dec 18 '23 | Sale | 88.84 | 616 | 54,726 | 249,448 | Dec 19 04:41 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Oct 12 '23 | Option Exercise | 0.00 | 3,125 | 0 | 305,246 | Oct 16 05:36 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Oct 13 '23 | Sale | 52.39 | 1,245 | 65,227 | 304,001 | Oct 16 05:36 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Sep 23 '23 | Option Exercise | 0.00 | 2,594 | 0 | 303,131 | Sep 26 04:40 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Sep 25 '23 | Sale | 55.20 | 1,010 | 55,753 | 302,121 | Sep 26 04:40 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Sep 15 '23 | Option Exercise | 0.00 | 1,562 | 0 | 301,159 | Sep 19 06:38 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Sep 18 '23 | Sale | 63.22 | 622 | 39,324 | 300,537 | Sep 19 06:38 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jul 12 '23 | Option Exercise | 0.00 | 3,125 | 0 | 300,600 | Jul 14 04:55 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jul 13 '23 | Sale | 89.74 | 1,204 | 108,048 | 299,396 | Jul 14 04:55 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jul 01 '23 | Option Exercise | 0.00 | 3,907 | 0 | 299,011 | Jul 05 05:57 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jul 03 '23 | Sale | 89.77 | 1,536 | 137,886 | 297,475 | Jul 05 05:57 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jun 23 '23 | Option Exercise | 0.00 | 2,593 | 0 | 296,139 | Jun 27 05:40 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jun 26 '23 | Sale | 85.78 | 1,035 | 88,781 | 295,104 | Jun 27 05:40 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jun 15 '23 | Option Exercise | 0.00 | 1,563 | 0 | 294,137 | Jun 20 04:54 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jun 16 '23 | Sale | 100.93 | 591 | 59,652 | 293,546 | Jun 20 04:54 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Apr 12 '23 | Option Exercise | 0.00 | 3,125 | 0 | 293,810 | Apr 14 05:06 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Apr 13 '23 | Sale | 134.51 | 1,236 | 166,260 | 292,574 | Apr 14 05:06 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Apr 01 '23 | Option Exercise | 0.00 | 3,906 | 0 | 292,271 | Apr 04 06:12 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Apr 03 '23 | Sale | 131.36 | 1,586 | 208,333 | 290,685 | Apr 04 06:12 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Mar 23 '23 | Option Exercise | 0.00 | 10,375 | 0 | 292,650 | Mar 27 04:42 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Mar 24 '23 | Sale | 128.01 | 4,285 | 548,541 | 288,365 | Mar 27 04:42 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Mar 15 '23 | Option Exercise | 0.00 | 1,562 | 0 | 282,872 | Mar 17 04:34 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Mar 16 '23 | Sale | 129.81 | 597 | 77,494 | 282,275 | Mar 17 04:34 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Feb 27 '23 | Sale | 127.72 | 11,692 | 1,493,270 | 281,310 | Feb 27 09:53 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Feb 21 '23 | Sale | 124.79 | 5,000 | 623,947 | 267,784 | Feb 22 07:07 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Feb 22 '23 | Sale | 123.24 | 5,000 | 616,207 | 262,784 | Feb 22 07:07 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Feb 10 '23 | Sale | 121.00 | 5,000 | 604,997 | 282,784 | Feb 14 06:47 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Feb 13 '23 | Sale | 126.35 | 5,000 | 631,744 | 277,784 | Feb 14 06:47 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Feb 14 '23 | Sale | 125.83 | 5,000 | 629,137 | 272,784 | Feb 14 06:47 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jan 12 '23 | Option Exercise | 0.00 | 3,125 | 0 | 289,010 | Jan 17 04:52 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jan 13 '23 | Sale | 120.56 | 1,226 | 147,803 | 287,784 | Jan 17 04:52 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jan 01 '23 | Option Exercise | 0.00 | 3,906 | 0 | 287,497 | Jan 04 07:23 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jan 04 '23 | Sale | 109.73 | 1,612 | 176,892 | 285,885 | Jan 04 07:23 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Dec 15 '22 | Option Exercise | 0.00 | 1,563 | 0 | 284,203 | Dec 19 04:56 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Dec 16 '22 | Sale | 109.79 | 612 | 67,191 | 283,591 | Dec 19 04:56 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Nov 01 '22 | Sale | 113.39 | 5,000 | 566,938 | 284,307 | Nov 02 06:06 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Oct 27 '22 | Sale | 108.68 | 5,000 | 543,424 | 299,307 | Oct 31 06:46 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Oct 28 '22 | Sale | 110.83 | 5,000 | 554,148 | 294,307 | Oct 31 06:46 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Oct 31 '22 | Sale | 116.97 | 5,000 | 584,847 | 289,307 | Oct 31 06:46 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Oct 12 '22 | Option Exercise | 0.00 | 3,125 | 0 | 305,525 | Oct 14 04:39 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Oct 13 '22 | Sale | 79.22 | 1,218 | 96,486 | 304,307 | Oct 14 04:39 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Oct 01 '22 | Option Exercise | 0.00 | 3,906 | 0 | 303,852 | Oct 05 04:14 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Oct 03 '22 | Sale | 84.77 | 1,452 | 123,084 | 302,400 | Oct 05 04:14 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Sep 15 '22 | Option Exercise | 0.00 | 1,562 | 0 | 300,593 | Sep 19 07:25 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Sep 16 '22 | Sale | 87.95 | 647 | 56,901 | 299,946 | Sep 19 07:25 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Aug 22 '22 | Sale | 92.08 | 5,000 | 460,423 | 304,031 | Aug 23 06:13 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Aug 23 '22 | Sale | 92.53 | 5,000 | 462,668 | 299,031 | Aug 23 06:13 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Aug 16 '22 | Sale | 96.31 | 5,000 | 481,536 | 314,031 | Aug 18 04:36 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Aug 17 '22 | Sale | 95.34 | 5,000 | 476,718 | 309,031 | Aug 18 04:36 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jul 12 '22 | Option Exercise | 0.00 | 3,125 | 0 | 320,273 | Jul 14 04:18 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jul 13 '22 | Sale | 64.46 | 1,242 | 80,056 | 319,031 | Jul 14 04:18 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jul 01 '22 | Option Exercise | 0.00 | 3,907 | 0 | 318,621 | Jul 06 04:52 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jul 05 '22 | Sale | 57.03 | 1,473 | 84,007 | 317,148 | Jul 06 04:52 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jun 15 '22 | Option Exercise | 0.00 | 1,563 | 0 | 315,360 | Jun 17 04:21 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jun 16 '22 | Sale | 47.93 | 646 | 30,964 | 314,714 | Jun 17 04:21 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Apr 12 '22 | Option Exercise | 0.00 | 12,500 | 0 | 318,621 | Apr 14 04:44 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Apr 13 '22 | Sale | 52.39 | 4,824 | 252,747 | 313,797 | Apr 14 04:44 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Apr 01 '22 | Option Exercise | 0.00 | 3,906 | 0 | 307,616 | Apr 05 04:37 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Apr 04 '22 | Sale | 64.54 | 1,495 | 96,484 | 306,121 | Apr 05 04:37 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Mar 15 '22 | Option Exercise | 0.00 | 1,562 | 0 | 304,298 | Mar 17 05:48 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Mar 16 '22 | Sale | 60.68 | 588 | 35,678 | 303,710 | Mar 17 05:48 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Feb 16 '22 | Sale | 70.00 | 5,000 | 350,000 | 303,034 | Feb 17 06:07 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Feb 14 '22 | Sale | 68.12 | 9,626 | 655,702 | 293,747 | Feb 15 04:36 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Dec 15 '21 | Option Exercise | 0.00 | 1,563 | 0 | 277,984 | Dec 17 07:18 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Dec 16 '21 | Sale | 81.18 | 670 | 54,392 | 277,314 | Dec 17 07:18 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Nov 04 '21 | Sale | 78.87 | 10,000 | 788,733 | 276,421 | Nov 08 04:36 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Nov 04 '21 | Sale | 78.87 | 20,000 | 1,577,466 | 619,998 | Nov 08 04:36 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Nov 02 '21 | Sale | 75.26 | 5,000 | 376,302 | 291,421 | Nov 04 06:10 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Nov 03 '21 | Sale | 76.52 | 5,000 | 382,613 | 286,421 | Nov 04 06:10 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Oct 01 '21 | Option Exercise | 0.00 | 3,906 | 0 | 298,024 | Oct 05 05:18 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Oct 04 '21 | Sale | 53.78 | 1,603 | 86,215 | 296,421 | Oct 05 05:18 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Sep 15 '21 | Option Exercise | 0.00 | 1,562 | 0 | 294,719 | Sep 17 05:58 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Sep 16 '21 | Sale | 55.69 | 601 | 33,471 | 294,118 | Sep 17 05:58 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jul 01 '21 | Option Exercise | 0.00 | 3,907 | 0 | 294,703 | Jul 06 07:21 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jul 02 '21 | Sale | 49.63 | 1,546 | 76,728 | 293,157 | Jul 06 07:21 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jun 15 '21 | Option Exercise | 0.00 | 6,250 | 0 | 293,288 | Jun 17 04:54 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jun 16 '21 | Sale | 49.49 | 2,492 | 123,325 | 290,796 | Jun 17 04:54 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Apr 01 '21 | Option Exercise | 0.00 | 3,906 | 0 | 288,581 | Apr 05 05:14 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Apr 05 '21 | Sale | 58.73 | 1,543 | 90,623 | 287,038 | Apr 05 05:14 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Mar 04 '21 | Option Exercise | 33.77 | 2,961 | 99,993 | 284,675 | Mar 05 04:43 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Mar 01 '21 | Sale | 65.14 | 12,150 | 791,443 | 281,714 | Mar 02 06:28 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jan 13 '21 | Sale | 54.25 | 10,000 | 542,468 | 659,999 | Jan 14 09:28 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jan 14 '21 | Sale | 55.96 | 10,000 | 559,627 | 649,999 | Jan 14 09:28 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jan 11 '21 | Sale | 50.00 | 10,000 | 500,000 | 273,227 | Jan 12 04:49 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jan 11 '21 | Sale | 50.00 | 10,000 | 500,000 | 679,999 | Jan 12 04:49 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jan 12 '21 | Sale | 54.04 | 10,000 | 540,433 | 263,227 | Jan 12 04:49 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jan 12 '21 | Sale | 53.96 | 9,280 | 500,729 | 670,719 | Jan 12 04:49 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jan 08 '21 | Option Exercise | 21.81 | 2,339 | 51,014 | 283,227 | Jan 08 05:07 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jan 01 '21 | Option Exercise | 0.00 | 3,906 | 0 | 276,247 | Jan 06 06:20 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jan 04 '21 | Option Exercise | 21.81 | 14,000 | 305,340 | 290,247 | Jan 06 06:20 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jan 06 '21 | Sale | 44.82 | 9,359 | 419,503 | 280,888 | Jan 06 06:20 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Dec 23 '20 | Sale | 45.00 | 2,280 | 102,600 | 272,341 | Dec 28 05:00 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Nov 30 '20 | Sale | 40.00 | 5,000 | 200,000 | 274,621 | Dec 02 07:08 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Nov 30 '20 | Sale | 40.00 | 10,000 | 400,000 | 689,999 | Dec 02 07:08 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Nov 17 '20 | Option Exercise | 21.81 | 2,000 | 43,620 | 279,621 | Nov 18 04:34 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Nov 16 '20 | Sale | 35.00 | 5,000 | 175,000 | 277,621 | Nov 18 04:34 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Oct 01 '20 | Option Exercise | 0.00 | 3,906 | 0 | 284,176 | Oct 02 07:19 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Oct 02 '20 | Sale | 28.33 | 1,555 | 44,055 | 282,621 | Oct 02 07:19 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jul 01 '20 | Option Exercise | 0.00 | 15,625 | 0 | 287,898 | Jul 06 06:48 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jul 02 '20 | Sale | 27.12 | 6,073 | 164,722 | 281,825 | Jul 06 06:48 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Mar 03 '20 | Sale | 25.48 | 11,595 | 295,416 | 272,273 | Mar 03 07:42 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jan 02 '20 | Option Exercise | 2.14 | 41,869 | 89,651 | 247,347 | Jan 06 05:14 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Nov 12 '19 | Sale | 35.01 | 9,500 | 332,576 | 205,478 | Nov 14 06:14 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Sep 17 '19 | Sale | 35.00 | 10,000 | 350,000 | 224,978 | Sep 18 06:42 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Sep 06 '19 | Sale | 35.50 | 10,000 | 355,006 | 235,478 | Sep 09 05:56 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Sep 09 '19 | Sale | 35.22 | 500 | 17,612 | 234,978 | Sep 09 05:56 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jul 19 '19 | Sale | 35.00 | 10,000 | 350,000 | 253,021 | Jul 22 04:49 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jul 22 '19 | Sale | 35.00 | 7,543 | 264,005 | 245,478 | Jul 22 04:49 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jul 15 '19 | Sale | 35.00 | 10,000 | 350,000 | 271,278 | Jul 16 05:35 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jul 16 '19 | Sale | 35.00 | 8,257 | 288,995 | 263,021 | Jul 16 05:35 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jul 11 '19 | Sale | 35.00 | 4,200 | 147,000 | 281,278 | Jul 12 05:21 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | May 20 '19 | Sale | 25.00 | 10,000 | 250,000 | 285,478 | May 22 05:21 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | May 15 '19 | Sale | 27.29 | 10,000 | 272,900 | 315,478 | May 17 04:56 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | May 16 '19 | Sale | 28.17 | 10,000 | 281,700 | 305,478 | May 17 04:56 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | May 17 '19 | Sale | 28.00 | 10,000 | 280,000 | 295,478 | May 17 04:56 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Apr 22 '19 | Sale | 20.00 | 10,000 | 200,000 | 325,478 | Apr 23 05:49 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Apr 18 '19 | Sale | 20.00 | 10,000 | 200,000 | 335,478 | Apr 19 02:56 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Apr 12 '19 | Option Exercise | 1.20 | 15,000 | 18,000 | 345,478 | Apr 15 06:28 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Feb 07 '19 | Option Exercise | 0.00 | 1,666 | 0 | 333,478 | Feb 15 09:28 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Feb 23 '18 | Option Exercise | 1.20 | 10,000 | 12,000 | 331,812 | Feb 27 05:42 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Feb 02 '18 | Option Exercise | 1.20 | 10,000 | 12,000 | 321,812 | Feb 06 05:35 PM |
| PI | DIORIO CHRIS PH.D. | Chief Executive Officer | Jan 09 '18 | Option Exercise | 1.20 | 5,000 | 6,000 | 311,812 | Jan 11 04:28 PM |
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